MAO inhibitors or MAOi are substances that occur in medicines and plants. Previously, MAO inhibitors were also used as antidepressants because they prevent the breakdown of neurotransmitters, among other things. Neurotransmitters such as serotonin and dopamine are broken down by the enzyme MonoAmino-Oxidase. An MAO inhibitor or MAOi therefore prevents the effect of MAO and that ensures that neurotransmitters such as serotonin and dopamine are not broken down so quickly.
Tyramine is also broken down by MAO and this is necessary to prevent high blood pressure and cerebral hemorrhages. Tyramine can be a problem during the use of non-selective MAO inhibitors. This problem can be prevented by using selective MAO inhibitors instead of non selective MAO inhibitors. Another option is a tyramine restricted diet.
Read more about it here tyramine restricted diet
MAO inhibitors and psychedelics
Most psychedelics fall under Monoaminos and are therefore broken down by the MAO enzymes that are standard in our body (stomach, brain, etc.). Some psychedelics such as psilocybin / psilocin from truffles are broken down very slowly and work for about 4-6 hours. Other psychedelics such as DMT break down within 15 minutes, so it can't even reach the brain when taken orally. If you do a MAO inhibitor with DMT, the enzyme MAO will temporarily not work and DMT can reach the brain. The combination DMT and MAO inhibitor is called ayahuasca or anahuasca and the MAO inhibitor is necessary for the effect. The combination of psilocybin / psilocin with MAO inhibitors is called psilohuasca and the MAO inhibitor is not necessary, but it does provide a longer and deeper trip or it ensures that you can use less psilocybin / psilocin (as a saving).
Because when using psilocybin containing truffles or mushrooms there is no need to use MAO inhibitors, but that an MAO inhibitor can prolong and deepen the trip, this is done quite often in the form of psilohuasca. However, we think that a heavy MAO inhibitor gives too much risk (see above about tyramine). A milder MAO inhibitor such as the passion flower deepens and prolongs the trip without many additional risks. We think it is the best choice in terms of trip quality and health safety.
If you have a psychedelic ceremony organized by us, it can be done at your location throughout the Netherlands. You can put together your own group or undergo a ceremony individually. We can advise you what you can do as a preparation and which psychedelics would suit you. Most of our customers opt for truffle ceremonies based on truffles (tea with herbs, vitamins, minerals and truffles). Psiloflora(Tea of truffles, passion flower minerals and herbs) is now an increasingly chosen alternative. A smaller group opts for an LSD analogue. We also have experience with synthetic analogue of psilocin (visual and colorful trip). A few also use a super large dose of psychedelics (heroic dose) and we can also advise you on this.
Combining various (psychedelic) substances is possible and can work synergistically. We do not advise doing this on your own initiative as it can also cause health problems up to death.
Learn more about our services
The original post comes from the link below
Read more about our here psychedelic therapy in combination with treatment against depression, burnout, stress, fear, low self esteem, social anxiety, PTSD, insecurity and chronic inflammatory diseases.