Trip therapy: Psilocybin and psilocin

Psilocybin and psilocin

The psychedelic substance psilocybin and the psilocybin containing truffles/mushrooms are becoming more and more famous because of the therapeutic properties of this substance. However, it is not psilocybin but psilocin that causes the trip. Psilocybin is converted to psilocin by (stomach) acid and the enzyme phosphatase.

The different doses of psilocybin and psilocin

Magic mushrooms, truffles, psilohuasca, and psiloflora all contain psilocybin/psilocin that fall into the group of mind-altering and hallucinogenic drugs. Magic mushrooms and magic truffles contain the same active substances. The effects are variable and depend, among other things, on your personal sensitivity, character, your mood, the drug and the dose. The active substances psilocin and psilocybin are very similar to the body's own serotonin (the neurotransmitter). Our body converts psilocybin to psilocin. Psilocin can then mimic serotonin at the serotonin receptor, called the 5HT2a receptor. The effects of magic mushrooms arise due to the higher stimulation of the receptors.

For more in-depth information on psilocybin, read our blog here: action of psilocybin.


Less serotonin

Serotonin deficiency causes depression, anxiety, restlessness, appetite for sweets (which lowers serotonin even more) and even more ailments. All this creates a negative spiral in which you are susceptible to unhealthy addictions and you hardly get out of this negative spiral unless you change course drastically.

For more in-depth information on serotonin, read our blog here: serotonin and happiness.  



Temporarily high levels of serotonin, psilocin and psilocybin

By doing a trip session with magic mushrooms or magic truffles, you temporarily increase the stimulation of the serotonin receptors under supervision, whereby the negative feelings of a shortage of serotonin disappear into the background. The extent to which we increase that arousal therefore affects your mood and experience. The intensity of this experience is divided into triplevels.

The effect of truffles

The first effects are noticeable after about half an hour. The senses will work better. Colors become brighter, sounds sound intense and the perception of reality changes. Depending on the dose that has been chosen in consultation, more changes in perception will take place. The higher the dose, the higher the triplevel and the effects.

Truffle ceremony trip level Duration (h) Fitness
low dose 1-2 2-3 Beginner
medium dose 3-4 3-5 Beginner
High dose 4-5 4-6 Experience psychedelics
hero dose 5 5-8 More experienced

Read more here the triple levels of psychedelics

The original post comes from the link below

Trip therapy against depression, anxiety, stress, burnout and PTSD: Psilocybin and psilocin

Read more about our here psychedelic therapy in combination with treatment against depression, burnout, stress, fear, low self esteem, social anxiety, PTSD, insecurity and chronic inflammatory diseases.


Other names for psychedelic therapy: Ayahuasca, MDMA therapy, Truffle ceremony, mushroom ceremony, psilocybin ceremony.